Expanded nTreg New

Donor #: 287
Size: 1-2M cells/vial
Price: $ 700.00
In Stock: 4
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Donor Details

Blood Type : BNeg
Age : 49
Gender : Female
Ethnicity : Caucasian
Anticoagulant : Citrate
HLA-A : 03:01,68:01
HLA-B : 15:01,44:02
HLA-C : 03:03,07:04
HLA-DRβ 1 : 15:01,01:01
CMV : Positive

Additional Donor Information:

This Treg population is obtained by ex vivo expansion of nTreg (Tregs isolated directly from blood). The expanded nTregs show the classical regulatory T cell phenotype, i.e., CD4+, CD25hi, and CD127-. In addition, the majority of the cells show intracellular expression of FoxP3 and surface expression of TIGIT. These nTregs also have the capacity to suppress in vitro T cell proliferation (e.g., anti-CD3 driven or MLR).

Healthy CMV positive donor. She has allergies to sulfa, cipro and cataflam.

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About Natural T Regulatory Cells

Natural T regulatory cells (nTregs) are a subset of T cells capable of suppressing the activation and expansion of other T cells. nTregs develop in the thymus, while the more commonly used induced Tregs (iTregs) are differentiated in the lab. Our nTregs express the most widely accepted phenotype for Tregs with a co-expression of CD4 and CD25 with additional intracellular expression of FoxP3 and absence of CD127.