SLE CD8+ T Cells

Donor #: 367
Size: 05-10M cells/vial
Price: $ 892.00
In Stock: 9
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Donor Details

Blood Type : Unknown
Age : 58
Gender : Female
Ethnicity : Caucasian
Donor Health : SLE
HLA-A : 01,24
HLA-B : 08,15
HLA-C : 03,07
HLA-DRβ 1 : 09,11
CMV : Unknown

Additional Donor Information:

Donor is 5′ 9″ and weighs 194 lbs. She has lupus. She takes several medications including Methotrexate and Plaquenil. All are listed on the certificate of analysis provided with each lot.

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About CD8+ T Cells

Our CD8+ T cells are purified from PBMC using negative immunomagnetic selection. CD8+ T cells make up one-third of the T cells in peripheral blood and are important in eliminating viruses and tumor cells. CD8+ T cells are quiescent until they encounter a peptide antigen bound to an MHC class I molecule, which are responsible for binding bits of proteins synthesized within each cell.

When a virus infects a cell and directs production of viral proteins, they are presented to CD8+ T cells by MHC class I molecules. The CD8+ T cells respond by dividing to create more antigen-specific CD8+ T cells to fight the infection.

Antigen-specific CD8+ T cells are polyclonal T cell lines derived by repeated activation with antigen-presenting cells and peptide antigen. We verify the response of the T cells to the peptide antigen of interest and determine the percentage of antigen reactive cells using HLA-peptide multimers. These T cells can be used in assays on the day they are thawed for ease of use in your experiments.

Naïve CD8+ T cells are those cells that have not encountered their cognate antigen and do not have a defined function.

Memory CD8+ T cells are T cells that have previously encountered antigen and have differentiated to central memory or effector memory cells.

Total CD8+ T cells are isolated from PBMC by negative immunomagnetic selection. They contain both naïve and memory T cells and can be used to derive antigen-specific T cells to your antigen of interest.

We have CD8+ T cells from a variety of donors in a range of vial sizes. All donors are HLA typed and tested negative for blood-borne pathogens.