CD8+ T Cells
| Donor #: | 153 |
|---|---|
| Size: | 05-10M cells/vial |
| Price: | $595.00 |
| In Stock: | 9 |
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Donor Details
| Blood Type : | OPos |
|---|---|
| Age : | 32 |
| Gender : | Female |
| Ethnicity : | Caucasian |
| Anticoagulant : | Citrate |
| HLA-A : | 02:01,31:01 |
| HLA-B : | 15:01,57:01 |
| HLA-C : | 03:03,06:02 |
| HLA-DRβ 1 : | 15:01,13:01 |
| CMV : | Positive |
Additional Donor Information:
Female, CMV positive and Fc gamma RIIIa 153-F/F. This donor is allergic to lorabid and cats. She also has a history of allergy to dust mites and local pollens.
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About CD8+ T Cells
Our CD8+ T cells are purified from PBMC using negative immunomagnetic selection. CD8+ T cells make up one-third of the T cells in peripheral blood and are important in eliminating viruses and tumor cells. CD8+ T cells are quiescent until they encounter a peptide antigen bound to an MHC class I molecule, which are responsible for binding bits of proteins synthesized within each cell.
When a virus infects a cell and directs production of viral proteins, they are presented to CD8+ T cells by MHC class I molecules. The CD8+ T cells respond by dividing to create more antigen-specific CD8+ T cells to fight the infection.
Antigen-specific CD8+ T cells are polyclonal T cell lines derived by repeated activation with antigen-presenting cells and peptide antigen. We verify the response of the T cells to the peptide antigen of interest and determine the percentage of antigen reactive cells using HLA-peptide multimers. These T cells can be used in assays on the day they are thawed for ease of use in your experiments.
Naïve CD8+ T cells are those cells that have not encountered their cognate antigen and do not have a defined function.
Memory CD8+ T cells are T cells that have previously encountered antigen and have differentiated to central memory or effector memory cells.
Total CD8+ T cells are isolated from PBMC by negative immunomagnetic selection. They contain both naïve and memory T cells and can be used to derive antigen-specific T cells to your antigen of interest.
We have CD8+ T cells from a variety of donors in a range of vial sizes. All donors are HLA typed and tested negative for blood-borne pathogens.