SLE CD4+ T Cells

Donor #: 367
Size: 05-10M cells/vial
Price: $ 705.00
In Stock: 33
Need More?
Request additional quantity

Donor Details

Blood Type : Unknown
Age : 58
Gender : Female
Ethnicity : Caucasian
Donor Health : SLE
HLA-A : 01,24
HLA-B : 08,15
HLA-C : 03,07
HLA-DRβ 1 : 09,11
CMV : Unknown

Additional Donor Information:

Donor is 5′ 9″ and weighs 194 lbs. She has lupus. She takes several medications including Methotrexate and Plaquenil. All are listed on the certificate of analysis provided with each lot.

Need something more unique?
Submit a custom request.

About CD4+ T Cells

Our CD4+ T cells are purified from PBMC using negative immunomagnetic selection. CD4+ T cells make up two-thirds of the T cells in peripheral blood. While they were originally considered helper T cells, we now know that there are subsets within the CD4+ population with distinct functions:

Antigen-specific CD4+ T cells are polyclonal T cell lines derived by repeated activation with antigen-presenting cells and peptide antigen. We verify the response of the T cells to the peptide antigen of interest and determine the HLA Class II allele responsible for presenting the antigen to the T cells. These T cells can be used in assays on the day they are thawed for ease of use in your experiments.

Naïve CD4+ T cells are those cells that have not encountered their cognate antigen and do not have a defined function. They are shown to express CD45RA, as expected in this T cell population.

Memory CD4+ T cells are those cells that have engaged with a peptide antigen bound to an MHC class II molecule. They have a particular function such as follicular helper cells, Th1 providing cytokines for cytotoxic T cells, or Th2 supporting differentiation of B cells.

Total CD4+ T cells contain both naïve and memory T cells and are ideal for mixed lymphocyte cultures or any assay measuring the response to an exogenous antigen.

We have CD4+ T cells from a variety of donors. All donors are HLA typed and tested negative for blood-borne pathogens.