Memory CD4+ Cells

Donor #: 345
Size: 05-10M cells/vial
Price: $ 495.00
In Stock: 1
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Donor Details

Blood Type : OPos
Age : 40
Gender : Male
HLA-A : 31,32
HLA-B : 07,40
HLA-C : 03,07
HLA-DRβ 1 : 04,15
CMV : Negative

Additional Donor Information:

Memory CD4+ Cells are T cells that have been exposed to their cognate antigens in vivo. They are selected based on expression of CD45RO.

Donor is 6′ 1″ and weighs 250 lbs. He is FcgRIIIa F/F

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About CD4+ T Cells

Our CD4+ T cells are purified from PBMC using negative immunomagnetic selection. CD4+ T cells make up two-thirds of the T cells in peripheral blood. While they were originally considered helper T cells, we now know that there are subsets within the CD4+ population with distinct functions:

Antigen-specific CD4+ T cells are polyclonal T cell lines derived by repeated activation with antigen-presenting cells and peptide antigen. We verify the response of the T cells to the peptide antigen of interest and determine the HLA Class II allele responsible for presenting the antigen to the T cells. These T cells can be used in assays on the day they are thawed for ease of use in your experiments.

Naïve CD4+ T cells are those cells that have not encountered their cognate antigen and do not have a defined function. They are shown to express CD45RA, as expected in this T cell population.

Memory CD4+ T cells are those cells that have engaged with a peptide antigen bound to an MHC class II molecule. They have a particular function such as follicular helper cells, Th1 providing cytokines for cytotoxic T cells, or Th2 supporting differentiation of B cells.

Total CD4+ T cells contain both naïve and memory T cells and are ideal for mixed lymphocyte cultures or any assay measuring the response to an exogenous antigen.

We have CD4+ T cells from a variety of donors. All donors are HLA typed and tested negative for blood-borne pathogens.