Memory CD4+ Cells
| Donor #: | 345 |
|---|---|
| Size: | 05-10M cells/vial |
| Price: | $ 495.00 |
| In Stock: | 1 |
| Need More? | |
| Request additional quantity |
Donor Details
| Blood Type : | OPos |
|---|---|
| Age : | 40 |
| Gender : | Male |
| HLA-A : | 31,32 |
| HLA-B : | 07,40 |
| HLA-C : | 03,07 |
| HLA-DRβ 1 : | 04,15 |
| CMV : | Negative |
Additional Donor Information:
Memory CD4+ Cells are T cells that have been exposed to their cognate antigens in vivo. They are selected based on expression of CD45RO.
Donor is 6′ 1″ and weighs 250 lbs. He is FcgRIIIa F/F
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About CD4+ T Cells
Our CD4+ T cells are purified from PBMC using negative immunomagnetic selection. CD4+ T cells make up two-thirds of the T cells in peripheral blood. While they were originally considered helper T cells, we now know that there are subsets within the CD4+ population with distinct functions:
Antigen-specific CD4+ T cells are polyclonal T cell lines derived by repeated activation with antigen-presenting cells and peptide antigen. We verify the response of the T cells to the peptide antigen of interest and determine the HLA Class II allele responsible for presenting the antigen to the T cells. These T cells can be used in assays on the day they are thawed for ease of use in your experiments.
Naïve CD4+ T cells are those cells that have not encountered their cognate antigen and do not have a defined function. They are shown to express CD45RA, as expected in this T cell population.
Memory CD4+ T cells are those cells that have engaged with a peptide antigen bound to an MHC class II molecule. They have a particular function such as follicular helper cells, Th1 providing cytokines for cytotoxic T cells, or Th2 supporting differentiation of B cells.
Total CD4+ T cells contain both naïve and memory T cells and are ideal for mixed lymphocyte cultures or any assay measuring the response to an exogenous antigen.
We have CD4+ T cells from a variety of donors. All donors are HLA typed and tested negative for blood-borne pathogens.
