Central Memory CD4+

Donor #: 399
Size: 05-10M cells/vial
Price: $ 675.00
In Stock: 2
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Donor Details

Blood Type : APos
Age : 24
Gender : Male
Ethnicity : Caucasian
Anticoagulant : Citrate
HLA-A : 03,31
HLA-B : 15,44
HLA-C : 03,05
HLA-DRβ 1 : 04,10
CMV : Negative

Additional Donor Information:

Donor is healthy but does take fluoxetine 20 mg. He is a non-smoker. His genotype for FcgRIIIa is F/V.

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About CD4+ T Cells

Our CD4+ T cells are purified from PBMC using negative immunomagnetic selection. CD4+ T cells make up two-thirds of the T cells in peripheral blood. While they were originally considered helper T cells, we now know that there are subsets within the CD4+ population with distinct functions:

Antigen-specific CD4+ T cells are polyclonal T cell lines derived by repeated activation with antigen-presenting cells and peptide antigen. We verify the response of the T cells to the peptide antigen of interest and determine the HLA Class II allele responsible for presenting the antigen to the T cells. These T cells can be used in assays on the day they are thawed for ease of use in your experiments.

Naïve CD4+ T cells are those cells that have not encountered their cognate antigen and do not have a defined function. They are shown to express CD45RA, as expected in this T cell population.

Memory CD4+ T cells are those cells that have engaged with a peptide antigen bound to an MHC class II molecule. They have a particular function such as follicular helper cells, Th1 providing cytokines for cytotoxic T cells, or Th2 supporting differentiation of B cells.

Total CD4+ T cells contain both naïve and memory T cells and are ideal for mixed lymphocyte cultures or any assay measuring the response to an exogenous antigen.

We have CD4+ T cells from a variety of donors. All donors are HLA typed and tested negative for blood-borne pathogens.