Tetanus Toxoid Specific T Cells

Donor #: 213
Size: 1-2M cells/vial
Price: $ 525.00
In Stock: 117
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Donor Details

Blood Type : ONeg
Age : 27
Gender : Female
Ethnicity : Caucasian
Donor Health : Healthy
Anticoagulant : Unknown
HLA-A : 02:01,02:01
HLA-B : 35,56
HLA-C : 01,04
HLA-DRβ 1 : 11,01
CMV : Negative

Additional Donor Information:

These CD4+ T cells are specific for a peptide (QYIKANSKFIGITEL) derived from tetanus toxoid bound to HLA-DRB1*01. They also recognize whole tetanus toxoid but only when presented by dendritic cells, not B-LCL.
The T cells proliferate when stimulated with antigen and APC. They also produce IFNg, IL-5, IL-10, and IL-13.

Healthy female donor, CMV negative. 5′ 10″ tall, 210 lbs. Her genotype at Fc gamma RIII alpha 158 is F/V.

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About Antigen-Specific T Cells

Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.

The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.

We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.