CMV Specific CD4+ T cell line

Donor #: 401
Size: 1-2M cells/vial
Price: $ 525.00
In Stock: 98
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Donor Details

Blood Type : ANeg
Age : 30
Gender : Female
Ethnicity : Caucasian
Donor Health : Healthy
Anticoagulant : Unknown
HLA-A : 02:01,02:01
HLA-B : 18,40
HLA-C : 03,07
HLA-DRβ 1 : 08,12
CMV : Positive

Additional Donor Information:

When stimulated in vitro with CMV lysate antigen, these CD4+ T cells show a specific proliferative response along with secretion of IFN-gamma, IL-5 and IL-13, but not IL-10. A majority of the T cell population are CD45RO+, CD45RA-, CD62L+, CD127+ and CD28+.

Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F

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About Antigen-Specific T Cells

Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.

The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.

We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.