Anti Myelin Basic Protein T Cells

Donor #: 3
Size: 1-2M cells/vial
Price: $ 525.00
In Stock: 38
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Donor Details

Blood Type : Unknown
Age : 56
Gender : Male
Ethnicity : Caucasian
Donor Health : Healthy
Anticoagulant : Unknown
HLA-A : 02:01,02:01
HLA-B : 14,27:05
HLA-DRβ 1 : 15:01,14
CMV : Positive

Additional Donor Information:

The BC3 cell line was isolated from a normal 56 year old Caucasian man. In vitro stimulation of peripheral blood mononuclear cells (PBMC) with a peptide of MBP was used to select for peptide reactive T cells. The peptide used (ENPVVHFFKNIVTPRTP) is believed to be the immunodominant epitope. The cells also recognize the peptide FFKNIVTPRTPPPSQGK, thus the minimal epitope for this line is FFKNIVTPRTP.
The cells secrete interferon gamma, IL-13 and TNF alpha upon stimulation. They are CD4+ and, not surprisingly, FoxP3 negative.

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About Antigen-Specific T Cells

Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.

The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.

We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.