Anti MART-1 T Cells, HLA-A*0201 Restricted New

Donor #: 358
Size: 1-2M cells/vial
Price: $ 525.00
In Stock: 22
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Donor Details

Blood Type : OPos
Age : 52
Gender : Female
Ethnicity : Caucasian
HLA-A : 02:01,02:01
HLA-B : 44:02,15:01
HLA-C : 03:03,05:01
HLA-DRβ 1 : 01:03,04:04
CMV : Negative

Additional Donor Information:

MART-1 (Melanoma Antigen Recognized by T cells), also known as Melan-A, is a 118 amino acid long surface protein expressed mainly on melanocytes and most melanoma. This anti MART-1 T cells are CD8+ T cells with specificity to the naturally processed native MART-1 (27-35) 9-mer: AAGIGILTV. These T cells also recognize the analog peptide: ELAGIGILTV, a 10-mer (26-35) with L for A substitution in position 27.

Donor is 5′ 6″ tall and weighs 230 lbs. She has allergies to sulfa drugs and takes Synthroid for thyroid problem. She is F/F at Fc gamma RIII alpha 158.

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About Antigen-Specific T Cells

Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.

The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.

We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.