Anti HPV E7(11-20) T Cells New

Donor #: 224
Size: 1-2M cells/vial
Price: $ 525.00
In Stock: 9
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Donor Details

Blood Type : BNeg
Age : 55
Gender : Female
Ethnicity : Caucasian
Anticoagulant : Unknown
HLA-A : 02:01,02:01
HLA-B : 07,15
HLA-C : 03,07
HLA-DRβ 1 : 15,13
CMV : Positive

Additional Donor Information:

These are CD8+ T cells specific for the E7 protein of human papilloma virus. The antigenic peptide sequence is YMLDLQPETT representing residues 11-20 of the protein and it is presented by the HLA-A*02:01 allele. The peptide is available on our Antigens page.

This donor is CMV positive and Fc gamma RIIIa F/F. She is 5′ 3″ tall and weighs 180 lbs.

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About Antigen-Specific T Cells

Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.

The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.

We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.