Proinsulin (73-90) Peptide 1mg New
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Antigen
| Size: | 1 mg/vial |
|---|---|
| Price: | $95.00 |
| In Stock: | 64 |
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Donor Details
| Anticoagulant : | Unknown |
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Additional Donor Information:
Proinsulin is considered an important autoantigen in type 1 diabetes (T1D). Autoreactivity to Proinsulin is very common in T1D patients with the HLA-DRB1*0401 haplotype. The Proinsulin 73-90 peptide (GAGSLQPLALEGSLQKRG) has been identified as an immunodominant T cell epitope of HLA-DRB1*0401 subjects with beta-islet cell autoimmunity.
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About Peptides
T cells recognize antigens in the form of short peptides. For CD8+ T cells, the peptides are typically 8–10 amino acids in length, while CD4+ T cells recognize longer peptides of 12–20 amino acids. Alterations of the amino acid sequence can dramatically affect T cell activation. Our peptides are synthesized, and purity is confirmed by HLPC and mass spectrometry.