Anti Influenza (M1) T Cells, HLA-A*0201-Restricted

Donor #: 401
Size: 1-2M cells/vial
Price: $550.00
In Stock: 1
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Donor Details

Blood Type : ANeg
Age : 31
Gender : Female
Ethnicity : Caucasian
Anticoagulant : Unknown
HLA-A : 02:01,02:01
HLA-B : 18:01,40:01
HLA-C : 03:04,07:01
HLA-DRβ 1 : 08:01,12:01
CMV : Positive

Additional Donor Information:

These cells are specific for the peptide sequence GILGFVFTL, found in the matrix protein of influenza virus. The peptide is presented (bound by) HLA-A*0201

Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F

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About Antigen-Specific T Cells

Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.

The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.

We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.