Anti WT-1 T cells New

Donor #: 398
Size: 1-2M cells/vial
Price: $ 525.00
In Stock: 6
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Donor Details

Blood Type : APos
Age : 45
Gender : Female
Ethnicity : Caucasian
HLA-A : 02:01,03:01
HLA-B : 07:02,39:01
HLA-C : 07:02,07:02
HLA-DRβ 1 : 08:01,15:01
CMV : Positive

Additional Donor Information:

This population contains >20% CD8 T cells specific to the WT-1 (Wilm’s Tumor gene product) peptide RMFPNAPYL (aa 126-134) presented by HLA-A*0201. WT-1 protein is overexpressed in leukemia and various solid cancers.

Donor has an allergy to kidney beans and seasonal allergies. She does not take any medications and does not smoke. She has the V/V genotype for FcgRIII alpha

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About Antigen-Specific T Cells

Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.

The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.

We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.