Anti-NY-ESO-1 ASTC, 1-2M cells New

Donor #: 401
Size: 1-2M cells/vial
Price: $600.00
In Stock: 127
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Donor Details

Blood Type : ANeg
Age : 31
Gender : Female
Ethnicity : Caucasian
Anticoagulant : Unknown
HLA-A : 02:01,02:01
HLA-B : 18:01,40:01
HLA-C : 03:04,07:01
HLA-DRβ 1 : 08:01,12:01
CMV : Positive

Additional Donor Information:

T cells specific for the tumor-associated antigen, NY-ESO-1. These cells recognize a peptide from NY-ESO-1 bound to HLA-A*02:01. The sequence of the peptide is SLLMWITQC (157-165).

Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F

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About Antigen-Specific T Cells

Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.

The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.

We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.