Anti-CMV CD4+ ASTC, 1-2M cells New
| Donor #: | 401 |
|---|---|
| Size: | 1-2M cells/vial |
| Price: | $600.00 |
| In Stock: | 74 |
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Donor Details
| Blood Type : | ANeg |
|---|---|
| Age : | 31 |
| Gender : | Female |
| Ethnicity : | Caucasian |
| Anticoagulant : | Unknown |
| HLA-A : | 02:01,02:01 |
| HLA-B : | 18:01,40:01 |
| HLA-C : | 03:04,07:01 |
| HLA-DRβ 1 : | 08:01,12:01 |
| CMV : | Positive |
Additional Donor Information:
When stimulated in vitro with CMV lysate antigen, these CD4+ T cells show a specific proliferative response along with secretion of IFN-gamma, IL-5 and IL-13, but not IL-10. A majority of the T cell population are CD45RO+, CD45RA-, CD62L+, CD127+ and CD28+.
Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F
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About Antigen-Specific T Cells
Antigen-specific T cells are unique tools for studying the immune system. The T cell receptor is, like immunoglobulin, generated by genetic rearrangement of multiple gene segments. This rearrangement creates an army of T cells, each directed against a unique peptide antigen.
The T cell repertoire responds to viruses, bacteria, tumor cells and, in the case of autoimmune disease, peptides derived from normal tissues. Each peptide specificity is only found in a small fraction of circulating T cells, making study of antigen-specific reactions difficult.
We have developed T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.