Type 1 diabetes affects approximately 1.25 million Americans today, and that number is expected to rise dramatically to 5 million by 2050.
In addition to its own health complications, diabetes can be a dangerous and deadly comorbidity for patients exposed to viruses, diseases, or other health challenges. As we have seen with the COVID-19 pandemic, people with diabetes are at a higher risk of serious health issues if exposed to the virus.
The current global health situation makes understanding and treating type 1 diabetes more critical than ever, as people with well-managed diabetes will likely be better positioned to fight off infections.
Supporting Diabetes Researchers
We’ve put our extensive network of blood donors and nationwide collection centers to work to source biomaterials from type 1 diabetics for use in research and development. We have isolated PBMC from several type 1 diabetes blood donors and generated exclusive antigen-specific T cell lines to support diabetes research efforts. Learn more about each below.
Type 1 Diabetes PBMC
We currently have large lots of these in-demand disease-state PBMC from ten different donors. If you’re researching type 1 diabetes or developing potential treatments, you’ll want to get your hands on these powerful cells.
Each product is available in vial sizes of 5 million cells/vial, 20 million cells/vial, or 50 million cells/vial so you can buy only what you need with no waste.
Anti-GAD65 T Cells
GAD65 antibodies are an important biomarker of nonneurological central nervous system autoimmune diseases, and more specifically, are an important marker for the development of type 1 diabetes. The GAD65 glutamic acid decarboxylase 65-kilodalton isoform is the first antigen to be recognized in diabetic subjects.
Recognizing GAD65 autoimmunity can be critical for identifying associated nonneurological diseases as well as assessing immunotherapy response potential. Our anti-GAD65 T cells are CD4+ T cell lines that recognize peptide 555–567 (NFFRMVISNPAAT).
Proinsulin-Specific T Cells
Type 1 diabetes is characterized by the loss of beta cells in the pancreas. When these beta cells die, the production of insulin declines and blood glucose levels increase uncontrollably. The death of these beta cells is widely believed to be the result of an autoimmune process, and researchers have discovered T cells and antibodies directed against beta cell antigens in people with type 1 diabetes.
Our proinsulin-specific T cells are an ideal tool for understanding the role of autoimmunity in type 1 diabetes. These cells can be used to test various methods that may either limit their pathogenic potential or render them harmless.
Due to the popularity of these cells, we are currently out of stock. You can request proinsulin-specific T cells and we will alert you when we have more ready.
Need More Diabetes Research Help?
If you have specific product questions or need help from our contract research professionals, get in touch with us today!