Our scientists have been working hard to develop an antigen-specific T cell line directed against the spike protein of SARS-CoV-2, the virus that causes COVID-19. The line is now available on our website for purchase.

Preliminary studies, such as this one in Cell, suggest a T cell defense against COVID-19 found in infected individuals and in those not known to be infected — likely from a previous infection of another coronavirus.

Source: DOI: https://doi.org/10.1016/j.cell.2020.05.015

In Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals, Grifoni et al. describe:

  • Measuring immunity to SARS-CoV-2 is key to understanding COVID-19 and vaccine development
  • Epitope pools detect CD4+ and CD8+ T cells in 100% and 70% of convalescent COVID patients
  • T cell responses are focused not only on spike but also on M, N, and other ORFs
  • T cell reactivity to SARS-CoV-2 epitopes is also detected in non-exposed individuals

 

Related Products: COVID-19 PBMC Available, COVID-19 Plasma Available

 

COVID-19-Specific T Cells for Vaccine Development and Research

Our new COVID-19-specific T cell line is HLA*0201-restricted and recognizes the epitope at residues 424–433 and is 90% identical to the corresponding region of SARS.

The donor is healthy and not known to be positive for novel coronavirus.

The anti-SARS-CoV-2 T cells will lyse cells that are given the peptide. While we predict these antigen-specific T cells will lyse infected cells, this has not yet been confirmed.

With over 100 vials in stock, you can purchase a small amount or large batch to support your coronavirus research and development efforts.

 

Not Back in the Lab Yet?

Contact us to reserve your COVID-19-specific T cells for when you’re back to work.

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