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As the basic mechanism that allows our bodies to identify, target, and kill infected or damaged cells, cell-mediated cytotoxicity is an essential function of our immune system and one that scientists continue to explore to develop more advanced immunotherapies. By better understanding the role of T cells and natural killer cells as effector cells and…
We have published several detailed research protocols on our website to help you improve cell performance and optimize your experimental outputs. Two of our protocols have garnered questions from our customers and readers. Namely, what’s the difference between the Recall Antigen Assay and the Antigen-Specific T Cell Assay? In this post, we explain the different…
Our scientists bring a wealth of immunology research expertise from diverse backgrounds. With extensive experience in a variety of biologics disciplines, our team is an ideal resource for a wide range of outsource research services. From multiplex assays to flow cytometric analyses, we help you get on with discovery. In this Researcher Spotlight, we introduce…
We field a ton of questions from research scientists related to stem cells. While the use cases for stem cells are vast, many researchers aren’t exactly sure where to start, especially if they’ve never worked with these powerful hematopoietic cells before. That’s why we’ve created a simple guide to answer some of our most frequently…
Research champions come in many forms. Not all of them wear white coats and goggles. Some have never even stepped foot in a lab, held a pipette, or know what an assay is. These unsung, anonymous research champions are our blood donors. To honor their critical contributions to medical research, we’ll be introducing you to…
The Online Mendelian Inheritance in ManⓇ website, or OMIMⓇ, is a publicly available catalog of over 15,000 human genes and all known genetic disorders updated daily by the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins University. Intended for physician and research use, OMIM is a searchable index of clinical features, phenotypes, genes, and more.…
Though macrophages were first described by Elie Metchnikoff in 1882, there are still plenty of mysteries associated with these versatile immune cells. We field many questions from curious scientists wanting to learn more about macrophages: What Are the Best Methods for Culturing These Cells? What’s the best culture medium? Do you need to add serum?…
If you’re a frequent buyer of mouse macrophages, you may have noticed a change in our product catalog. Starting in April 2019, we switched from peritoneal macrophages to bone marrow-derived macrophages; a small change for us that can have a big impact on your research. Why the Change? In short, we made the change because…
What Are Cytokine Measurement Assays? Cytokine measurement assays are sensitive measures for both primary cell assays and purified antigen-specific cultures. Detecting the presence of cytokines — small proteins that are secreted by immune cells to signal an immune or inflammatory response — can help researchers better understand how our bodies respond to invading pathogens. Common…
Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alpha and antigen binding domains Bernett, Matthew et al. “The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or…