T-Scan: A genome-wide method for the systematic discovery of T cell epitopes Kula et al. describe a new method for discovering T cell epitopes that does not require the culture of T cells and allows for precise mapping of T cells to the peptides they recognize. Cellero Cells Used: PBMC Inhibitory effect of Acer tegmentosum…
Do you have a pesky little habit you just can’t kick? One that’s hard to ignore because you’re reminded of it everywhere you turn? Your friends are doing it, your colleagues are doing it, even your parents are doing it! (If they are research scientists.) We are, of course, talking about the habit of focusing…
Immune therapy to fight cancer specifically programs a patient’s own immune system to target & destroy invading disease cells. The ability of immunotherapy to more strategically combat cancer than general cancer treatments do is only now being fully understood. And as scientists excitedly recognize immunotherapies’ potential is far greater than first imagined, donor blood cells…
Great news for those of you who have been waiting for new T regulatory cells (Tregs): We have hundreds of vials back in stock ready for overnight shipping to your lab! Head over to our product listings to see our current inventory. Induced Tregs Natural Tregs New to Tregs? Learn About Your Options. As…
What Is Surface Antigen Expression? Surface antigens, or cell markers, are a handy way for scientists to classify cells based on cell type and function, which is beneficial for early-stage research as well as disease diagnosis and treatment. The cluster of differentiation (CD) nomenclature was adopted in the early 1980s and serves as a global…
Mice have long been used as a model system for studying the human immune system, from which many basic principles of immunology have been uncovered. As discoveries made using mouse models show promise for therapeutic development for human patients, human-mouse models can serve as an ideal model of the human immune system prior to clinical…
Blood Stem Cells Power Supply Blood stem cells produce billions of new blood cells daily, providing the 3 blood cell types that sustain human life: Oxygen-carrying red blood cells, Clot-forming platelets that stop bleeding, Disease-fighting white blood cells Without constant new blood cell production, survival is threatened. Blood Stem Cells Only Make More Blood Cells…
Antigen-specific T cells have many excellent use cases in the lab for early-stage research and discovery. As we continue to develop novel antigen-specific T cell lines — including those specific to tumors, diabetes, and viruses — more use cases are coming to light. If you’re working in an academic or biopharma research lab, consider antigen-specific…
Peripheral blood mononuclear cells (PBMC) play a critical role in our understanding of the human immune system and developing life-saving and life-altering treatments. With plays in immunology, inflammation, toxicology, vaccination, and other fields, scientists in all areas need to have a deep understanding of this ready-made blend of innate and adaptive immune cells. We’ve created…
White blood cells play a vital immune system role as weapons against illness and disease. One kind of white blood cell in particular, peripheral blood mononuclear cells (PMNCs or simply MNCs), circulates through the body targeting bacteria, viruses – and even cancer. Bacterial and viral invader cells generally are killed by MNCs; but cancer cells…