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A curious researcher recently asked us to suggest suitable antigens that could stimulate IFNγ producing CD8+ T cells. The short answer: Virus proteins. But as with anything in immunology and virology, there is a longer, more complicated explanation as well. Protein Antigens vs. Peptide Antigens CD8+ T cells normally recognize antigens that are produced…
What is the HER2 Antigen? HER2 is a tumor-related antigen also known as ERBB2 or NEU. The HER2 gene encodes a human epidermal growth factor receptor (EGFR) that is overexpressed by several tumor types, most notably in breast and ovarian cancers. Many women (and men) are interested to know their HER2 status. HER2 gene amplification…
For decades, medical professionals and researchers have relied on and even preferred stem cells derived from bone marrow for transplantation and research purposes. When bone marrow transplantation began in 1956, this was the only way to harness the body’s most versatile cells. In the nearly 65 years since the first successful bone marrow transplant, there…
The CAR-TCR Summit is heading to London! We will be represented at the show by our partners from Key Biologics, who will be ready to meet you at booth A10. If you’re working to engineer a cancer-free world, come talk to us about how we can help with cell sourcing in the UK and…
How many donors would it take to cover all of the HLA types? It’s a question I’ve been asked several times over the years but have struggled to answer with clarity. HLA genes are the most diverse in the human genome. With multiple genes having hundreds if not thousands of alleles, an accurate answer to…
Laurie Vertuccio named Director of Marketing and Rhonda Lyons named Director of Operations MEMPHIS, Tenn. and BOTHELL, Wash. — Jan. 30, 2020 — Key Biologics, the leading provider of research- and clinical-grade human immune cells, blood products, and related services to the biopharmaceutical industry, today announced it has hired two new executives to support its recent growth…
Phacilitate 2020 was jam-packed with inspiration, motivation, and confirmation that what we are doing is making an impact on patient lives now and into the future. We attended several educational sessions, met with many scientists, and had countless conversations about the future of immunotherapy. Here are some of our top Phacilitate 2020 highlights. 2020…
TCRβ sequencing is currently being explored in oncology research as a potential predictor for patient response to immunotherapies. Researchers from Biodesix, Inc. shared their most recent findings in this area at the AACR Advances in Liquid Biopsies conference in Miami from January 13–16, 2020. The research, co-authored by our Benjamin Tjoa, evaluated peripheral blood lymphocytes…
Our cryopreserved peripheral blood mononuclear cells are a great tool for flow cytometry assays. Whether you want to confirm your antibodies are working properly or measure for consistency, our PBMC are the tools you need for quality control. Using PBMC to Test Antibodies Sometimes you might not be sure if your chosen reagent is correctly…
Our resident dendritic cell expert, Benjamin Tjoa, was one of the first scientists in the world to develop dendritic cells for use in cell-based vaccines. Ben has traveled internationally to help labs prepare for developing dendritic cell-based therapies. Monocyte-derived dendritic cells are a hot topic for many of our customers, and Ben has answered countless…