You might know that CD34+ stem cells can be sourced from three different locations: bone marrow, cord blood, and peripheral blood. But does it matter which source you use for your CD34+ cells? And do you know the different functions and best use cases for each? We’ll help you find the right stem cell source…
Specialty drugs — often described as “prescription drugs that are difficult to manufacture and require special handling or administration, have limited distribution, target a narrow group of chronic diseases, are costly, and require ongoing clinical support — will drive nearly all of the pharmaceutical industry’s market growth from 2015–2020. Drug Channels projects the total pharmaceutical…
We wrote a post back in November 2016 comparing natural human T regulatory cells and induced human T regulatory cells. While both have unique benefits and are great options for studying the immune system, you also have a third option for Tregs: mouse T regulatory cells. You may not think of mouse Tregs for immune-oncology…
We are happy to announce the availability of an expanded list of SLE donors in our immune cell catalog. In partnership with Physicians Plasma Alliance, we have isolated PBMC, purified CD4+ T cells, and purified CD8+ T cells from donors with SLE (Systemic Lupus Erythematosis). Although Physicians Plasma Alliance is located in Tennessee, we are…
We frequently get requests for blood cell donors who have a certain disease: Can I get a donor with rheumatoid arthritis? Do you have donors with lung cancer? Can I get PBMC from a pregnant donor? Do you have cells from a donor with vitiligo? You get the idea. These requests come in on…
When ordering human or animal immune cells for research, it’s important to know as many details about the products as possible. That’s why we provide a detailed Certificate of Analysis for each cell product we offer. But beyond knowing information about the cells and donors, you should also inquire about your supplier’s collection and processing…
Mouse bone marrow cells are a multipurpose resource for conversion to several other useful cell types. Mouse bone marrow contains hematopoietic stem cells, which makes it an excellent starting point for deriving cells of various hematopoietic lineages. Converting Mouse Bone Marrow to Other Cells: 3 Examples 1) Bone Marrow to Macrophages When cultured in…
At the 2017 ASCO-SITC Clinical Immuno-Oncology Symposium in Orlando, researchers from Biodesix presented a poster featuring our cells. The poster, “Development of ddPCR blood-based diagnostic tests that simultaneously measure mRNA expression from immune and cancer cells,” demonstrates how Biodesix developed sensitive and specific methods that can be applied in gene expression studies in blood. These…
Complexity is the operative word in Pharm Exec’s 2017 Pipeline Report. Complex diseases are driving the development of new and innovative therapies while the market adjusts to manufacturing challenges and increasing drug costs. We’ve recapped some of the main topics in the report, including CAR-T therapies, combination treatments and nonalcoholic steatohepatitis (NASH), among others. …
CMV antigens and CMV peptides are both great tools for studying the implications of the human cytomegalovirus (CMV), which infects nearly 1/3 of children before the age of five and more than half of adults in the U.S. Although CMV-infected individuals are often asymptomatic, the virus does pose a serious threat to individuals with weakened…