Useful Tools in Immunology: OMIM.org

The Online Mendelian Inheritance in ManⓇ website, or OMIMⓇ, is a publicly available catalog of over 15,000 human genes and all known genetic disorders updated daily by the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins University. Intended for physician and research use, OMIM is a searchable index of clinical features, phenotypes, genes, and more.…

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Upcoming Webinar: The Mysterious World of Macrophages

Though macrophages were first described by Elie Metchnikoff in 1882, there are still plenty of mysteries associated with these versatile immune cells. We field many questions from curious scientists wanting to learn more about macrophages: What Are the Best Methods for Culturing These Cells? What’s the best culture medium?  Do you need to add serum?…

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Now Offering Bone Marrow-Derived Mouse Macrophages

If you’re a frequent buyer of mouse macrophages, you may have noticed a change in our product catalog. Starting in April 2019, we switched from peritoneal macrophages to bone marrow-derived macrophages; a small change for us that can have a big impact on your research. Why the Change? In short, we made the change because…

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Immunology for Non-Immunologists: Cytokine Measurement

What Are Cytokine Measurement Assays? Cytokine measurement assays are sensitive measures for both primary cell assays and purified antigen-specific cultures. Detecting the presence of cytokines — small proteins that are secreted by immune cells to signal an immune or inflammatory response — can help researchers better understand how our bodies respond to invading pathogens. Common…

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Cells in Motion: Recent Patent Applications

Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alpha and antigen binding domains Bernett, Matthew et al. “The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or…

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What Are Irradiated PBMC? Learn About Our Newest Product.

Sometimes researchers need access to the components and benefits of normal peripheral blood mononuclear cells, but don’t want the cells to proliferate in their experiments. That’s where irradiated PBMC come in handy. Learn more about our newest immune cell product below. What Are Irradiated PBMC? Irradiated PBMC are normal PBMC that have been exposed to…

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What We Learned at AACR 2019

We all know that CAR-T therapies and immune checkpoint inhibitors are game-changers for oncology, and both were on display at the American Association for Cancer Research’s annual meeting held in Atlanta last week. Although both therapies have produced spectacular results in some patients, neither work for all patients and efforts must now turn to understanding…

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Ask A Scientist: Immunology Acronym Confusion

With so many acronyms used in the field of immunology, things can get confusing and mistakes can be costly. Acronyms are useful devices to reduce long, sometimes tongue-twisting terms into manageable shorthand, but do add confusion to those newer to the field.    We’ve cleared up several of these situations through the years via our…

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New Resource for Antigen-Specific T Cells

Antigen-specific T cells are a powerful tool for understanding human immunity and developing treatments and cures for our most prolific diseases. Luckily, they are more readily available to researchers than ever before. Not only have we devoted many resources over the past several years to developing an exclusive inventory of antigen-specific T cells for use…

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AACR 2019 Restaurant Guide: Atlanta

We are headed to the American Association for Cancer Research’s 2019 annual meeting in Atlanta! We will be at the show from March 31 – April 3 in booth #4907 to answer your immunology research questions and highlight our latest immune cell developments. If you will be in Atlanta for AACR, save this list of…

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