About Herpes Simplex Virus
HSV causes cold sores, ocular disease and genital lesions. About 48% Americans ages 14 to 49 carry HSV-1 and 12% of the same population carry HSV-2, but many show no symptoms or suffer nothing more than the occasional cold sore. While often innocuous, the virus can cause more serious infections of the eye leading to blindness and can prove fatal when passed to newborns.
Due to the widespread occurrence of the complex and currently incurable virus, combined with the potentially lethal consequences of transmission, it’s an important virus to study for vaccine development and treatment.
New: HSV-Specific T Cells
Our latest antigen-specific T cell line is CD8+ and specific for an epitope from glycoprotein D of HSV. Glycoprotein D is immunogenic for both CD4+ and CD8+ T cells and could be important in developing HSV vaccines.
The HSV-specific T cell line is our third T cell line directed against a member of the larger Herpesvirus family, all of which establish chronic, latent infections in humans. We also have Epstein-Barr Virus-Specific T Cells and Cytomegalovirus-Specific T Cells for further discovery of the Herpesvirus family.
Understanding the biology of this virus family is essential to controlling the various health issues they cause.