T-Scan: A genome-wide method for the systematic discovery of T cell epitopes
Kula et al. describe a new method for discovering T cell epitopes that does not require the culture of T cells and allows for precise mapping of T cells to the peptides they recognize.
Cellero Cells Used: PBMC
Inhibitory effect of Acer tegmentosum maxim extracts on P. gingivalis LPS-induced periodontitis
Choi et al. show how Acer tegmentosum Maxim (ATM) could be used as a natural anti-periodontitis agent to prevent periodontal disease, a type of chronic inflammation.
Cellero Product Used: Lipopolysaccharides (LPS)
CD47 antibodies and uses thereof for treating cancer
Gardai, Shyra et al.
“Methods for using anti-CD47 antibodies, including masked antibodies, to modulate activity of (e.g., inhibit proliferation of) a CD47-expressing cell, as well as for the treatment of one or more diseases or disorders (e.g., cancer) associated with CD47-expressing cells, are provided.”
Cellero Cells Used: Natural Killer (NK) Cells
Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases
“This invention provides for a fusion protein between an IL2αβγ Selective Agonist protein (IL2 Selective Agonist ) and a IgG Fc protein using a linker. The IL2 Selective Agonist moiety provides a therapeutic activity by selectively activating the IL2αβγ form of the receptor, thus selectively stimulating Tregs. The Fc moiety provides a prolonged circulating half-life compared to the circulating half-life of IL-2 or an IL2SA protein.”
Cellero Cells Used: CD4+ T Cells