Antigen-Specific T Cells in Breast Cancer An independent publication from a cancer research group at Indiana University cites using Cellero antigen-specific T cell products to examine mechanisms of immune evasion.[1] Immune surveillance is the human body’s strongest defense against invasive cancer cells. The uncanny ability to evade that surveillance and grow aggressively is exactly what…
HemaCare and Cellero are ringing in the New Year with the aspiration to be bigger and better! Both cell supply companies are joining forces under the umbrella of Massachusetts-based Charles River Laboratories. The new coalition is a major part of Charles River’s strategy to expand its research and development capacity, by acquiring the expertise needed…
Cellosaurus is a comprehensive online knowledge base that attempts to list and describe all known cell lines used in biomedical research. It features immortalized, naturally immortal, and finite life cell lines for vertebrates and invertebrates, but does not include primary cell lines or plant cell lines. Why We Love Cellosaurus 1. If you want…
By now, culturing monocytes to create myeloid dendritic cells should be old hat. The technique was first published by Sallusto and Lanzavecchia in 1994. In spite of the widespread use of this culture method, there are still questions about the best practices, time in culture, maturation, and other variables. We recently received a few questions…
As a lab scientist, you appreciate the access leukapheresis offers to high volumes of cells for your experiments all at once. Even if you don’t need a whole leukopak or you work with cryopreserved PBMC, it is incredibly handy to have a source of cells that is consistent and always ready to go. Scientists don’t…
Surplus. It’s any lab manager’s or researcher’s favorite word when it comes to the year-end budget! With the events of 2020 closing many labs for large chunks of the year, you may have more of a surplus than usual. So what to do with those funds? One good investment is well characterized immune cells, which…
Monocytes and macrophages are very closely related cells with a few important distinctions and different use cases. Put simply, monocytes are macrophages in the blood; macrophages are monocytes in tissue. Understanding the Difference Monocytes are the largest type of white blood cells and play an important role in the adaptive immunity process. Monocytes typically…
Today we are announcing the latest in our line-up of disease-state PBMC products: Celiac Disease PBMC! Celiac Disease has become increasingly prevalent over the past decade, both in medical diagnosis and global awareness. An estimated 3 million Americans have Celiac Disease, although 80% are undiagnosed. The best “treatment” for people who have Celiac Disease or…
We have created several different T cell lines specific for tumor-associated antigens, and now have developed and validated a cell-mediated cytotoxicity assay to see if the tumor antigens are presented by tumor cells to the cytotoxic T cells. Using the IncuCyte® S3 to Image Co-Cultures and Observe Cell Killing In this assay, we used…
For some scientists, the difference between serum and plasma is just nomenclature. On more than once occasion we’ve had to ask customers, “Do you mean serum or do you mean plasma?” only to hear, “either one” or “aren’t they the same thing?” Let us clear up the confusion. Serum vs. Plasma: What’s the Difference?…