Ask A Scientist: Is There an Alternative Measure of Autoimmune Disease Activity?

Many autoimmune diseases are characterized by the presence of antibodies to normal proteins. For example, in rheumatoid arthritis (RA), it’s typical to see antibodies to citrullinated peptides. In Systemic lupus erythematosus (SLE), antibodies to double-stranded DNA and other nuclear proteins are hallmarks of the disease. Physicians use these different antibody reactivity patterns to distinguish autoimmune…